Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL

The Notch pathway is frequently activated in T-cell acute lymphoblastic leukemias (T-ALLs). Of the Notch receptors, Notch1 is a recurrent target of gain-of-function mutations and Notch3 is expressed in all T-ALLs, but it is currently unclear how these receptors contribute to T-cell transformation in...

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Hauptverfasser: Jeannet, Robin, Mastio, Jérôme, Macias-Garcia, Alejandra, Oravecz, Attila, Ashworth, Todd, Geimer Le Lay, Anne-Solen, Jost, Bernard, Le Gras, Stéphanie, Ghysdael, Jacques, Gridley, Thomas, Honjo, Tasuku, Radtke, Freddy, Aster, Jon C., Chan, Susan, Kastner, Philippe
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2010
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Plenary Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100247/
https://ncbi.nlm.nih.gov/pubmed/20829372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-05-286658
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