Reduced Paneth cell α-defensins in ileal Crohn's disease

The pathogenesis of Crohn′s disease (CD), an idiopathic inflammatory bowel disease, is attributed, in part, to intestinal bacteria that may initiate and perpetuate mucosal inflammation in genetically susceptible individuals. Paneth cells (PC) are the major source of antimicrobial peptides in the sma...

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Autors principals: Wehkamp, Jan, Salzman, Nita H., Porter, Edith, Nuding, Sabine, Weichenthal, Michael, Petras, Robert E., Shen, Bo, Schaeffeler, Elke, Schwab, Matthias, Linzmeier, Rose, Feathers, Ryan W., Chu, Hiutung, Lima, Heriberto, Fellermann, Klaus, Ganz, Tomas, Stange, Eduard F., Bevins, Charles L.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2005
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1306791/
https://ncbi.nlm.nih.gov/pubmed/16330776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505256102
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