A Chromosome 8 Gene-Cluster Polymorphism with Low Human Beta-Defensin 2 Gene Copy Number Predisposes to Crohn Disease of the Colon

Defensins are endogenous antimicrobial peptides that protect the intestinal mucosa against bacterial invasion. It has been suggested that deficient defensin expression may underlie the chronic inflammation of Crohn disease (CD). The DNA copy number of the beta-defensin gene cluster on chromosome 8p2...

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Asıl Yazarlar: Fellermann, Klaus, Stange, Daniel E., Schaeffeler, Elke, Schmalzl, Hartmut, Wehkamp, Jan, Bevins, Charles L., Reinisch, Walter, Teml, Alexander, Schwab, Matthias, Lichter, Peter, Radlwimmer, Bernhard, Stange, Eduard F.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society of Human Genetics 2006
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1559531/
https://ncbi.nlm.nih.gov/pubmed/16909382
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