NOD2 (CARD15) mutations in Crohn’s disease are associated with diminished mucosal α-defensin expression

Background: Mutations in NOD2, a putative intracellular receptor for bacterial peptidoglycans, are associated with a subset of Crohn’s disease but the molecular mechanism linking this protein with the disease pathogenesis remains unclear. Human α defensins (HD-5 and HD-6) are antibiotic effector mol...

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Bibliografiska uppgifter
Huvudupphovsmän: Wehkamp, J, Harder, J, Weichenthal, M, Schwab, M, Schäffeler, E, Schlee, M, Herrlinger, K R, Stallmach, A, Noack, F, Fritz, P, Schröder, J M, Bevins, C L, Fellermann, K, Stange, E F
Materialtyp: Artigo
Språk:Inglês
Publicerad: Copyright 2004 by Gut 2004
Ämnen:
Inflammatory Bowel Disease
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1774270/
https://ncbi.nlm.nih.gov/pubmed/15479689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2003.032805
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