Reduced mucosal antimicrobial activity in Crohn's disease of the colon

OBJECTIVES: In order to maintain the mucosal barrier against luminal microorganisms the intestinal epithelial cells synthesise various broad‐spectrum antimicrobial peptides including defensins and cathelicidins. Recent studies indicate that both may be deficient in Crohn's disease. To elucidate...

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Bibliografiske detaljer
Main Authors: Nuding, Sabine, Fellermann, Klaus, Wehkamp, Jan, Stange, Eduard F
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Group 2007
Fag:
Inflammatory Bowel Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1954969/
https://ncbi.nlm.nih.gov/pubmed/17456510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2006.118646
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