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Reduced mucosal antimicrobial activity in Crohn's disease of the colon

OBJECTIVES: In order to maintain the mucosal barrier against luminal microorganisms the intestinal epithelial cells synthesise various broad‐spectrum antimicrobial peptides including defensins and cathelicidins. Recent studies indicate that both may be deficient in Crohn's disease. To elucidate...

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Detalhes bibliográficos
Main Authors: Nuding, Sabine, Fellermann, Klaus, Wehkamp, Jan, Stange, Eduard F
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1954969/
https://ncbi.nlm.nih.gov/pubmed/17456510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2006.118646
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