Reduced Paneth cell α-defensins in ileal Crohn's disease

The pathogenesis of Crohn′s disease (CD), an idiopathic inflammatory bowel disease, is attributed, in part, to intestinal bacteria that may initiate and perpetuate mucosal inflammation in genetically susceptible individuals. Paneth cells (PC) are the major source of antimicrobial peptides in the sma...

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Bibliografski detalji
Glavni autori: Wehkamp, Jan, Salzman, Nita H., Porter, Edith, Nuding, Sabine, Weichenthal, Michael, Petras, Robert E., Shen, Bo, Schaeffeler, Elke, Schwab, Matthias, Linzmeier, Rose, Feathers, Ryan W., Chu, Hiutung, Lima, Heriberto, Fellermann, Klaus, Ganz, Tomas, Stange, Eduard F., Bevins, Charles L.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2005
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1306791/
https://ncbi.nlm.nih.gov/pubmed/16330776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505256102
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