Crohn's disease-derived monocytes fail to induce Paneth cell defensins

Crohn’s disease (CD) is associated with a multitude of genetic defects, many of which likely affect Paneth cell function. Paneth cells reside in the small intestine and produce antimicrobial peptides essential for the host barrier, principally human α-defensin 5 (HD5) and HD6. Patients with CD of th...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Courth, Lioba F., Ostaff, Maureen J., Mailänder-Sánchez, Daniela, Malek, Nisar P., Stange, Eduard F., Wehkamp, Jan
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2015
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653149/
https://ncbi.nlm.nih.gov/pubmed/26512113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1510084112
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