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Crohn's disease-derived monocytes fail to induce Paneth cell defensins
Crohn’s disease (CD) is associated with a multitude of genetic defects, many of which likely affect Paneth cell function. Paneth cells reside in the small intestine and produce antimicrobial peptides essential for the host barrier, principally human α-defensin 5 (HD5) and HD6. Patients with CD of th...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2015
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4653149/ https://ncbi.nlm.nih.gov/pubmed/26512113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1510084112 |
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