Asymmetric Structural Motions of the Homomeric α7 Nicotinic Receptor Ligand Binding Domain Revealed by Molecular Dynamics Simulation

A homology model of the ligand binding domain of the α7 nicotinic receptor is constructed based on the acetylcholine-binding protein crystal structure. This structure is refined in a 10 ns molecular dynamics simulation. The modeled structure proves fairly resilient, with no significant changes at th...

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Detalhes bibliográficos
Main Authors: Henchman, Richard H., Wang, Hai-Long, Sine, Steven M., Taylor, Palmer, McCammon, J. Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: Biophysical Society 2003
Assuntos:
Channels, Receptors, and Transporters
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1303578/
https://ncbi.nlm.nih.gov/pubmed/14581202
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