Potentials of Mean Force for Acetylcholine Unbinding from the Alpha7 Nicotinic Acetylcholine Receptor Ligand Binding Domain

The nicotinic acetylcholine receptor is a prototype ligand-gated ion channel that mediates signal transduction in the neuromuscular junctions and other cholinergic synapses. The molecular basis for the energetics of ligand binding and unbinding is critical to our understanding of the pharmacology of...

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Bibliographic Details
Main Authors: Zhang, Deqiang, Gullingsrud, Justin, McCammon, J. Andrew
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546508/
https://ncbi.nlm.nih.gov/pubmed/16506783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja057292u
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