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A gating mechanism proposed from a simulation of a human α7 nicotinic acetylcholine receptor

The nicotinic acetylcholine receptor is a well characterized ligandgated ion channel, yet a proper description of the mechanisms involved in gating, opening, closing, ligand binding, and desensitization does not exist. Until recently, atomic-resolution structural information on the protein was limit...

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Detalhes bibliográficos
Main Authors: Law, Richard J., Henchman, Richard H., McCammon, J. Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1100735/
https://ncbi.nlm.nih.gov/pubmed/15857954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407739102
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