APC-dependent suppression of colon carcinogenesis by PPARγ

Activation of PPARγ by synthetic ligands, such as thiazolidinediones, stimulates adipogenesis and improves insulin sensitivity. Although thiazolidinediones represent a major therapy for type 2 diabetes, conflicting studies showing that these agents can increase or decrease colonic tumors in mice hav...

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Detalhes bibliográficos
Main Authors: Girnun, Geoffrey D., Smith, Wendy M., Drori, Stavit, Sarraf, Pasha, Mueller, Elisabetta, Eng, Charis, Nambiar, Prashant, Rosenberg, Daniel W., Bronson, Roderick T., Edelmann, Winfried, Kucherlapati, Raju, Gonzalez, Frank J., Spiegelman, Bruce M.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC129773/
https://ncbi.nlm.nih.gov/pubmed/12370429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.162480299
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