APC-dependent suppression of colon carcinogenesis by PPARγ

Activation of PPARγ by synthetic ligands, such as thiazolidinediones, stimulates adipogenesis and improves insulin sensitivity. Although thiazolidinediones represent a major therapy for type 2 diabetes, conflicting studies showing that these agents can increase or decrease colonic tumors in mice hav...

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Bibliografiske detaljer
Main Authors: Girnun, Geoffrey D., Smith, Wendy M., Drori, Stavit, Sarraf, Pasha, Mueller, Elisabetta, Eng, Charis, Nambiar, Prashant, Rosenberg, Daniel W., Bronson, Roderick T., Edelmann, Winfried, Kucherlapati, Raju, Gonzalez, Frank J., Spiegelman, Bruce M.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC129773/
https://ncbi.nlm.nih.gov/pubmed/12370429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.162480299
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