APC-dependent suppression of colon carcinogenesis by PPARγ

Activation of PPARγ by synthetic ligands, such as thiazolidinediones, stimulates adipogenesis and improves insulin sensitivity. Although thiazolidinediones represent a major therapy for type 2 diabetes, conflicting studies showing that these agents can increase or decrease colonic tumors in mice hav...

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Bibliographic Details
Main Authors: Girnun, Geoffrey D., Smith, Wendy M., Drori, Stavit, Sarraf, Pasha, Mueller, Elisabetta, Eng, Charis, Nambiar, Prashant, Rosenberg, Daniel W., Bronson, Roderick T., Edelmann, Winfried, Kucherlapati, Raju, Gonzalez, Frank J., Spiegelman, Bruce M.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC129773/
https://ncbi.nlm.nih.gov/pubmed/12370429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.162480299
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