APC-dependent suppression of colon carcinogenesis by PPARγ

Activation of PPARγ by synthetic ligands, such as thiazolidinediones, stimulates adipogenesis and improves insulin sensitivity. Although thiazolidinediones represent a major therapy for type 2 diabetes, conflicting studies showing that these agents can increase or decrease colonic tumors in mice hav...

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Détails bibliographiques
Auteurs principaux: Girnun, Geoffrey D., Smith, Wendy M., Drori, Stavit, Sarraf, Pasha, Mueller, Elisabetta, Eng, Charis, Nambiar, Prashant, Rosenberg, Daniel W., Bronson, Roderick T., Edelmann, Winfried, Kucherlapati, Raju, Gonzalez, Frank J., Spiegelman, Bruce M.
Format: Artigo
Langue:Inglês
Publié: The National Academy of Sciences 2002
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC129773/
https://ncbi.nlm.nih.gov/pubmed/12370429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.162480299
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