Adenomatous Polyposis Coli (APC) Is Required for Normal Development of Skin and Thymus

The tumor suppressor gene Apc (adenomatous polyposis coli) is a member of the Wnt signaling pathway that is involved in development and tumorigenesis. Heterozygous knockout mice for Apc have a tumor predisposition phenotype and homozygosity leads to embryonic lethality. To understand the role of Apc...

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Autori principali: Kuraguchi, Mari, Wang, Xiu-Ping, Bronson, Roderick T, Rothenberg, Rebecca, Ohene-Baah, Nana Yaw, Lund, Jennifer J, Kucherlapati, Melanie, Maas, Richard L, Kucherlapati, Raju
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2006
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1564426/
https://ncbi.nlm.nih.gov/pubmed/17002498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.0020146
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