Loss of Rb1 in the gastrointestinal tract of Apc(1638N) mice promotes tumors of the cecum and proximal colon

To examine the role of Rb1 in gastrointestinal (GI) tumors, we generated mice with an Apc(1638N) allele, Rb(tm2brn) floxed alleles, and a villin-cre transgene (RBVCA). These animals had exon 19 deleted from Rb1 throughout the GI tract. We have shown previously that Rb1 deficiency is insufficient for...

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Detalhes bibliográficos
Main Authors: Kucherlapati, Melanie H., Yang, Kan, Fan, Kunhua, Kuraguchi, Mari, Sonkin, Dmitriy, Rosulek, Andrew, Lipkin, Martin, Bronson, Roderick T., Aronow, Bruce J., Kucherlapati, Raju
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2563082/
https://ncbi.nlm.nih.gov/pubmed/18832169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802933105
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