Loss of Rb1 in the gastrointestinal tract of Apc(1638N) mice promotes tumors of the cecum and proximal colon

To examine the role of Rb1 in gastrointestinal (GI) tumors, we generated mice with an Apc(1638N) allele, Rb(tm2brn) floxed alleles, and a villin-cre transgene (RBVCA). These animals had exon 19 deleted from Rb1 throughout the GI tract. We have shown previously that Rb1 deficiency is insufficient for...

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Bibliographic Details
Main Authors: Kucherlapati, Melanie H., Yang, Kan, Fan, Kunhua, Kuraguchi, Mari, Sonkin, Dmitriy, Rosulek, Andrew, Lipkin, Martin, Bronson, Roderick T., Aronow, Bruce J., Kucherlapati, Raju
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2563082/
https://ncbi.nlm.nih.gov/pubmed/18832169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802933105
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