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A two-state kinetic model for the unfolding of single molecules by mechanical force

We investigate the work dissipated during the irreversible unfolding of single molecules by mechanical force, using the simplest model necessary to represent experimental data. The model consists of two levels (folded and unfolded states) separated by an intermediate barrier. We compute the probabil...

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Bibliografiske detaljer
Main Authors: Ritort, F., Bustamante, C., Tinoco, I.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC129710/
https://ncbi.nlm.nih.gov/pubmed/12374867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.172525099
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