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Differential accessibility at the κ chain locus plays a role in allelic exclusion
Gene rearrangement in the immune system is always preceded by DNA demethylation and increased chromatin accessibility. Using a model system in which rearrangement of the endogenous immunoglobulin κ locus is prevented, we demonstrate that these epigenetic and chromatin changes actually occur on one a...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2002
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC129040/ https://ncbi.nlm.nih.gov/pubmed/12356741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf518 |
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