Differential accessibility at the κ chain locus plays a role in allelic exclusion
Gene rearrangement in the immune system is always preceded by DNA demethylation and increased chromatin accessibility. Using a model system in which rearrangement of the endogenous immunoglobulin κ locus is prevented, we demonstrate that these epigenetic and chromatin changes actually occur on one a...
Kaydedildi:
| Yayımlandı: | EMBO J |
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| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group
2002
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC129040/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12356741/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf518 |
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