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A novel Pax5-binding regulatory element in the Igκ locus

The Igκ locus undergoes a variety of different molecular processes during B cell development, including V(D)J rearrangement and somatic hypermutations, which are influenced by cis regulatory regions (RR) within the locus. The Igκ locus includes three characterized RRs termed the intronic (iEκ), 3’Eκ...

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Principais autores: Rena eLevin-Klein, Andrei eKirillov, Chaggai eRosenbluh, Howard eCedar, Yehudit eBergman
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014-05-01
coleção:Frontiers in Immunology
Assuntos:
DNA Methylation
B cell development
somatic hypermutation
Pax5
V(D)J Rearrangement
Acesso em linha:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00240/full
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