κ chain monoallelic demethylation and the establishment of allelic exclusion
Allelic exclusion in κ light-chain synthesis is thought to result from a feedback mechanism by which the expression of a functional κ light chain on the surface of the B cell leads to an intracellular signal that down-regulates the V(D)J recombinase, thus precluding rearrangement of the other allele...
Uloženo v:
| Vydáno v: | Genes Dev |
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| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Cold Spring Harbor Laboratory Press
1998
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316908/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9637682/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.12.1801 |
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