κ chain monoallelic demethylation and the establishment of allelic exclusion

Allelic exclusion in κ light-chain synthesis is thought to result from a feedback mechanism by which the expression of a functional κ light chain on the surface of the B cell leads to an intracellular signal that down-regulates the V(D)J recombinase, thus precluding rearrangement of the other allele...

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Bibliografiske detaljer
Main Authors: Mostoslavsky, Raul, Singh, Nandita, Kirillov, Andrei, Pelanda, Roberta, Cedar, Howard, Chess, Andrew, Bergman, Yehudit
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 1998
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC316908/
https://ncbi.nlm.nih.gov/pubmed/9637682
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