Structure-Function Relationships for Human Antibodies to Pneumococcal Capsular Polysaccharide from Transgenic Mice with Human Immunoglobulin Loci

To investigate the influence of antibody structure and specificity on antibody efficacy against Streptococcus pneumoniae, human monospecific antibodies (MAbs) to serotype 3 pneumococcal capsular polysaccharide (PPS-3) were generated from transgenic mice reconstituted with human immunoglobulin loci (...

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Detalhes bibliográficos
Main Authors: Chang, Q., Zhong, Z., Lees, A., Pekna, M., Pirofski, L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC128266/
https://ncbi.nlm.nih.gov/pubmed/12183544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.9.4977-4986.2002
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