Human Monoclonal Antibodies against Pseudomonas aeruginosa Lipopolysaccharide Derived from Transgenic Mice Containing Megabase Human Immunoglobulin Loci Are Opsonic and Protective against Fatal Pseudomonas Sepsis

Pseudomonas aeruginosa is a significant human pathogen, and no vaccine is commercially available. Passive antibody prophylaxis using monoclonal antibodies (MAb) against protective P. aeruginosa epitopes is an alternative strategy for preventing P. aeruginosa infection, but mouse MAb are not suitable...

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Detalhes bibliográficos
Main Authors: Hemachandra, Sonali, Kamboj, Kulwant, Copfer, Janna, Pier, Gerald, Green, Larry L., Schreiber, John R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC98149/
https://ncbi.nlm.nih.gov/pubmed/11254577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.4.2223-2229.2001
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