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Immunomodulatory Effects of Anti-CD4 Antibody in Host Resistance against Infections and Tumors in Human CD4 Transgenic Mice

Anti-CD4 antibodies, which cause CD4(+) T-cell depletion, have been shown to increase susceptibility to infections in mice. Thus, development of anti-CD4 antibodies for clinical use raises potential concerns about suppression of host defense mechanisms against pathogens and tumors. The anti-human CD...

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Detalhes bibliográficos
Main Authors: Herzyk, Danuta J., Gore, Elizabeth R., Polsky, Rodd, Nadwodny, Kimberly L., Maier, Curtis C., Liu, Susan, Hart, Timothy K., Harmsen, Allen G., Bugelski, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC97984/
https://ncbi.nlm.nih.gov/pubmed/11160000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.2.1032-1043.2001
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