Immunomodulatory Effects of Anti-CD4 Antibody in Host Resistance against Infections and Tumors in Human CD4 Transgenic Mice

Anti-CD4 antibodies, which cause CD4(+) T-cell depletion, have been shown to increase susceptibility to infections in mice. Thus, development of anti-CD4 antibodies for clinical use raises potential concerns about suppression of host defense mechanisms against pathogens and tumors. The anti-human CD...

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Pubblicato in:	Infect Immun
Autori principali:	Herzyk, Danuta J., Gore, Elizabeth R., Polsky, Rodd, Nadwodny, Kimberly L., Maier, Curtis C., Liu, Susan, Hart, Timothy K., Harmsen, Allen G., Bugelski, Peter J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Microbial Immunity and Vaccines
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97984/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11160000/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.69.2.1032-1043.2001
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