High Potency of Indolyl Aryl Sulfone Nonnucleoside Inhibitors towards Drug-Resistant Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutants Is Due to Selective Targeting of Different Mechanistic Forms of the Enzyme

Indolyl aryl sulfone (IAS) nonnucleoside inhibitors have been shown to potently inhibit the growth of wild-type and drug-resistant human immunodeficiency virus type 1 (HIV-1), but their exact mechanism of action has not been elucidated yet. Here, we describe the mechanism of inhibition of HIV-1 reve...

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Bibliographic Details
Main Authors: Cancio, Reynel, Silvestri, Romano, Ragno, Rino, Artico, Marino, De Martino, Gabriella, La Regina, Giuseppe, Crespan, Emmanuele, Zanoli, Samantha, Hübscher, Ulrich, Spadari, Silvio, Maga, Giovanni
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1280147/
https://ncbi.nlm.nih.gov/pubmed/16251294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.11.4546-4554.2005
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