Drug Resistance Mutations in the Nucleotide Binding Pocket of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Differentially Affect the Phosphorolysis-Dependent Primer Unblocking Activity in the Presence of Stavudine and Zidovudine and Its Inhibition by Efavirenz

Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) derivatives with D113E, Y115F, F116Y, Q151E/N, and M184V mutations were studied for their phosphorolysis-mediated resistance to the nucleoside RT inhibitors (NRTIs) zidovudine and stavudine and for their inhibition by the nonnucl...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Crespan, Emmanuele, Locatelli, Giada A., Cancio, Reynel, Hübscher, Ulrich, Spadari, Silvio, Maga, Giovanni
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2005
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC538890/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15616314/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.49.1.342-349.2005
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