Effects of Drug Resistance Mutations L100I and V106A on the Binding of Pyrrolobenzoxazepinone Nonnucleoside Inhibitors to the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Catalytic Complex

We have previously described a novel class of nonnucleoside reverse transcriptase (RT) inhibitors, the pyrrolobenzoxazepinone (PBO) and the pyridopyrrolooxazepinone (PPO) derivatives, which were effective inhibitors of human immunodeficiency virus type 1 (HIV-1) RT, either wild type or carrying know...

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Detalhes bibliográficos
Main Authors: Locatelli, Giada A., Campiani, Giuseppe, Cancio, Reynel, Morelli, Elena, Ramunno, Anna, Gemma, Sandra, Hübscher, Ulrich, Spadari, Silvio, Maga, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC400584/
https://ncbi.nlm.nih.gov/pubmed/15105107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.5.1570-1580.2004
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