Drug Resistance Mutations in the Nucleotide Binding Pocket of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Differentially Affect the Phosphorolysis-Dependent Primer Unblocking Activity in the Presence of Stavudine and Zidovudine and Its Inhibition by Efavirenz

Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) derivatives with D113E, Y115F, F116Y, Q151E/N, and M184V mutations were studied for their phosphorolysis-mediated resistance to the nucleoside RT inhibitors (NRTIs) zidovudine and stavudine and for their inhibition by the nonnucl...

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Detalhes bibliográficos
Main Authors: Crespan, Emmanuele, Locatelli, Giada A., Cancio, Reynel, Hübscher, Ulrich, Spadari, Silvio, Maga, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC538890/
https://ncbi.nlm.nih.gov/pubmed/15616314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.1.342-349.2005
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