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High Potency of Indolyl Aryl Sulfone Nonnucleoside Inhibitors towards Drug-Resistant Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutants Is Due to Selective Targeting of Different Mechanistic Forms of the Enzyme

Indolyl aryl sulfone (IAS) nonnucleoside inhibitors have been shown to potently inhibit the growth of wild-type and drug-resistant human immunodeficiency virus type 1 (HIV-1), but their exact mechanism of action has not been elucidated yet. Here, we describe the mechanism of inhibition of HIV-1 reve...

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Bibliographische Detailangaben
Hauptverfasser: Cancio, Reynel, Silvestri, Romano, Ragno, Rino, Artico, Marino, De Martino, Gabriella, La Regina, Giuseppe, Crespan, Emmanuele, Zanoli, Samantha, Hübscher, Ulrich, Spadari, Silvio, Maga, Giovanni
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1280147/
https://ncbi.nlm.nih.gov/pubmed/16251294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.11.4546-4554.2005
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