Mn(III) Pyrophosphate as an Efficient Tool for Studying the Mode of Action of Isoniazid on the InhA Protein of Mycobacterium tuberculosis

The antituberculosis drug isoniazid (INH) is quickly oxidized by stoichiometric amounts of manganese(III) pyrophosphate. In the presence of nicotinamide coenzymes (NAD(+), NADH, nicotinamide mononucleotide [NMN(+)]) and nicotinic acid adenine dinucleotide (DNAD(+)), INH oxidation produced the format...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Nguyen, Michel, Quémard, Annaïk, Broussy, Sylvain, Bernadou, Jean, Meunier, Bernard
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 2002
Sujets:	Mechanisms of Action: Physiological Effects
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127317/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12069966/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.7.2137-2144.2002
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