Mn(III) Pyrophosphate as an Efficient Tool for Studying the Mode of Action of Isoniazid on the InhA Protein of Mycobacterium tuberculosis

The antituberculosis drug isoniazid (INH) is quickly oxidized by stoichiometric amounts of manganese(III) pyrophosphate. In the presence of nicotinamide coenzymes (NAD(+), NADH, nicotinamide mononucleotide [NMN(+)]) and nicotinic acid adenine dinucleotide (DNAD(+)), INH oxidation produced the format...

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Bibliografische gegevens

Gepubliceerd in:	Antimicrob Agents Chemother
Hoofdauteurs:	Nguyen, Michel, Quémard, Annaïk, Broussy, Sylvain, Bernadou, Jean, Meunier, Bernard
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Microbiology (ASM) 2002
Onderwerpen:	Mechanisms of Action: Physiological Effects
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127317/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12069966/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.7.2137-2144.2002
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