Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA

AN12855 is a novel cofactor-independent inhibitor of Mycobacterium tuberculosis InhA. AN12855 has potent activity against M. tuberculosis , good oral bioavailability, and comparable efficacy to isoniazid in infection models. New antitubercular agents are needed to combat the spread of multidrug- and...

Descripció completa

Dades bibliogràfiques

Autors principals:	Yi Xia, Yasheen Zhou, David S Carter, Matthew B McNeil, Wai Choi, Jason Halladay, Pamela W Berry, Weimin Mao, Vincent Hernandez, Theresa O'Malley, Aaron Korkegian, Bjorn Sunde, Lindsay Flint, Lisa K Woolhiser, Michael S Scherman, Veronica Gruppo, Courtney Hastings, Gregory T Robertson, Thomas R Ioerger, Jim Sacchettini, Peter J Tonge, Anne J Lenaerts, Tanya Parish, MRK Alley
Format:	Artigo
Idioma:	Inglês
Publicat:	Life Science Alliance LLC 2018-06-01
Col·lecció:	Life Science Alliance
Accés en línia:	https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.201800025
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!