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Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA

AN12855 is a novel cofactor-independent inhibitor of Mycobacterium tuberculosis InhA. AN12855 has potent activity against M. tuberculosis , good oral bioavailability, and comparable efficacy to isoniazid in infection models. New antitubercular agents are needed to combat the spread of multidrug- and...

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Principais autores: Yi Xia, Yasheen Zhou, David S Carter, Matthew B McNeil, Wai Choi, Jason Halladay, Pamela W Berry, Weimin Mao, Vincent Hernandez, Theresa O'Malley, Aaron Korkegian, Bjorn Sunde, Lindsay Flint, Lisa K Woolhiser, Michael S Scherman, Veronica Gruppo, Courtney Hastings, Gregory T Robertson, Thomas R Ioerger, Jim Sacchettini, Peter J Tonge, Anne J Lenaerts, Tanya Parish, MRK Alley
Formato: Artigo
Idioma:Inglês
Publicado em: Life Science Alliance LLC 2018-06-01
coleção:Life Science Alliance
Acesso em linha:https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.201800025
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