Mn(III) Pyrophosphate as an Efficient Tool for Studying the Mode of Action of Isoniazid on the InhA Protein of Mycobacterium tuberculosis

The antituberculosis drug isoniazid (INH) is quickly oxidized by stoichiometric amounts of manganese(III) pyrophosphate. In the presence of nicotinamide coenzymes (NAD(+), NADH, nicotinamide mononucleotide [NMN(+)]) and nicotinic acid adenine dinucleotide (DNAD(+)), INH oxidation produced the format...

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Dades bibliogràfiques

Publicat a:	Antimicrob Agents Chemother
Autors principals:	Nguyen, Michel, Quémard, Annaïk, Broussy, Sylvain, Bernadou, Jean, Meunier, Bernard
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 2002
Matèries:	Mechanisms of Action: Physiological Effects
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127317/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12069966/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.7.2137-2144.2002
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