Mn(III) Pyrophosphate as an Efficient Tool for Studying the Mode of Action of Isoniazid on the InhA Protein of Mycobacterium tuberculosis

The antituberculosis drug isoniazid (INH) is quickly oxidized by stoichiometric amounts of manganese(III) pyrophosphate. In the presence of nicotinamide coenzymes (NAD(+), NADH, nicotinamide mononucleotide [NMN(+)]) and nicotinic acid adenine dinucleotide (DNAD(+)), INH oxidation produced the format...

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Detalhes bibliográficos
Main Authors: Nguyen, Michel, Quémard, Annaïk, Broussy, Sylvain, Bernadou, Jean, Meunier, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC127317/
https://ncbi.nlm.nih.gov/pubmed/12069966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.7.2137-2144.2002
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