Mn(III) Pyrophosphate as an Efficient Tool for Studying the Mode of Action of Isoniazid on the InhA Protein of Mycobacterium tuberculosis

The antituberculosis drug isoniazid (INH) is quickly oxidized by stoichiometric amounts of manganese(III) pyrophosphate. In the presence of nicotinamide coenzymes (NAD(+), NADH, nicotinamide mononucleotide [NMN(+)]) and nicotinic acid adenine dinucleotide (DNAD(+)), INH oxidation produced the format...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Nguyen, Michel, Quémard, Annaïk, Broussy, Sylvain, Bernadou, Jean, Meunier, Bernard
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2002
Schlagworte:	Mechanisms of Action: Physiological Effects
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127317/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12069966/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.7.2137-2144.2002
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