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Internal IgH class switch region deletions are position-independent and enhanced by AID expression

Ig heavy chain class switch recombination (CSR) involves a recombination/deletion mechanism that exchanges the expressed C(H) gene with a downstream C(H) gene. CSR is mediated by highly repetitive switch (S) region sequences and requires the activation-induced deaminase (AID). The S region 5′ of the...

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Bibliografiske detaljer
Main Authors: Dudley, Darryll D., Manis, John P., Zarrin, Ali A., Kaylor, Lianne, Tian, Ming, Alt, Frederick W.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2002
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC126611/
https://ncbi.nlm.nih.gov/pubmed/12114543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.152333499
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