Position-dependent inhibition of class-switch recombination by PGK-neo(r) cassettes inserted into the immunoglobulin heavy chain constant region locus

The Ig heavy chain (IgH) constant region (C(H)) genes are organized from 5′ to 3′ in the order Cμ, Cδ, Cγ3, Cγ1, Cγ2b, Cγ2a, Cɛ, and Cα. Expression of C(H) genes downstream of Cδ involves class-switch recombination (CSR), a process that is targeted by germ-line transcription (GT) of the correspondin...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Seidl, Katherine J., Manis, John P., Bottaro, Andrea, Zhang, Jue, Davidson, Laurie, Kisselgof, Alison, Oettgen, Hans, Alt, Frederick W.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15884/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10077626/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.6.3000
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!