Position-dependent inhibition of class-switch recombination by PGK-neo(r) cassettes inserted into the immunoglobulin heavy chain constant region locus

Eitemau Tebyg

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• Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions
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• Developmental regulation of DNA cytosine methylation at the immunoglobulin heavy chain constant locus
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• Requirement for enhancer specificity in immunoglobulin heavy chain locus regulation
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• Ku70 Is Required for Late B Cell Development and Immunoglobulin Heavy Chain Class Switching
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