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Position-dependent inhibition of class-switch recombination by PGK-neo(r) cassettes inserted into the immunoglobulin heavy chain constant region locus
The Ig heavy chain (IgH) constant region (C(H)) genes are organized from 5′ to 3′ in the order Cμ, Cδ, Cγ3, Cγ1, Cγ2b, Cγ2a, Cɛ, and Cα. Expression of C(H) genes downstream of Cδ involves class-switch recombination (CSR), a process that is targeted by germ-line transcription (GT) of the correspondin...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC15884/ https://ncbi.nlm.nih.gov/pubmed/10077626 |
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