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Trans-chromosomal recombination within the Ig heavy chain switch region in B lymphocytes
Somatic DNA rearrangements in B lymphocytes, including V(D)J gene rearrangements and isotype switching, generally occur in cis, i. e., intrachromosomally. We showed previously, however, that 3 to 7% of IgA heavy chains have the V(H) and Cα regions encoded in trans. To determine whether the trans-ass...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC21727/ https://ncbi.nlm.nih.gov/pubmed/9751752 |
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