Internal IgH class switch region deletions are position-independent and enhanced by AID expression

Ig heavy chain class switch recombination (CSR) involves a recombination/deletion mechanism that exchanges the expressed C(H) gene with a downstream C(H) gene. CSR is mediated by highly repetitive switch (S) region sequences and requires the activation-induced deaminase (AID). The S region 5′ of the...

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izdano v:	Proc Natl Acad Sci U S A
Principais autores:	Dudley, Darryll D., Manis, John P., Zarrin, Ali A., Kaylor, Lianne, Tian, Ming, Alt, Frederick W.
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 2002
Teme:	Biological Sciences
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126611/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12114543/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.152333499
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