DNA Damage-Induced Phosphorylation of MdmX at Serine 367 Activates p53 by Targeting MdmX for Mdm2-Dependent Degradation

Understanding how p53 activity is regulated is crucial in elucidating mechanisms of cellular defense against cancer. Genetic data indicate that Mdmx as well as Mdm2 plays a major role in maintaining p53 activity at low levels in nonstressed cells. However, biochemical mechanisms of how Mdmx regulate...

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Autori principali: Okamoto, Koji, Kashima, Kenji, Pereg, Yaron, Ishida, Michiko, Yamazaki, Satomi, Nota, Ayumi, Teunisse, Amina, Migliorini, Domenico, Kitabayashi, Issay, Marine, Jean-Christophe, Prives, Carol, Shiloh, Yosef, Jochemsen, Aart G., Taya, Yoichi
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
Soggetti:
Gene Expression
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1265801/
https://ncbi.nlm.nih.gov/pubmed/16227609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.21.9608-9620.2005
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