GH3, a novel proapoptotic domain in Drosophila Grim, promotes a mitochondrial death pathway
Grim encodes a protein required for programmed cell death in Drosophila. The Grim N-terminus induces apoptosis by disrupting IAP blockage of caspases; however, N-terminally-deleted Grim retains pro apoptotic activity. We describe GH3, a 15 amino acid internal Grim domain absolutely required for its...
保存先:
| 出版年: | EMBO J |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2002
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126101/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12093734/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf354 |
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