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GH3, a novel proapoptotic domain in Drosophila Grim, promotes a mitochondrial death pathway
Grim encodes a protein required for programmed cell death in Drosophila. The Grim N-terminus induces apoptosis by disrupting IAP blockage of caspases; however, N-terminally-deleted Grim retains pro apoptotic activity. We describe GH3, a 15 amino acid internal Grim domain absolutely required for its...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC126101/ https://ncbi.nlm.nih.gov/pubmed/12093734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf354 |
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