GH3, a novel proapoptotic domain in Drosophila Grim, promotes a mitochondrial death pathway

Grim encodes a protein required for programmed cell death in Drosophila. The Grim N-terminus induces apoptosis by disrupting IAP blockage of caspases; however, N-terminally-deleted Grim retains pro apoptotic activity. We describe GH3, a 15 amino acid internal Grim domain absolutely required for its...

Deskribapen osoa

Xehetasun bibliografikoak

Argitaratua izan da:	EMBO J
Egile Nagusiak:	Clavería, Cristina, Caminero, Eva, Martínez-A, Carlos, Campuzano, Sonsoles, Torres, Miguel
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Nature Publishing Group 2002
Gaiak:	Article
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126101/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12093734/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf354
Etiketak:	Etiketa erantsi Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!