GH3, a novel proapoptotic domain in Drosophila Grim, promotes a mitochondrial death pathway

Grim encodes a protein required for programmed cell death in Drosophila. The Grim N-terminus induces apoptosis by disrupting IAP blockage of caspases; however, N-terminally-deleted Grim retains pro apoptotic activity. We describe GH3, a 15 amino acid internal Grim domain absolutely required for its...

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Pubblicato in:	EMBO J
Autori principali:	Clavería, Cristina, Caminero, Eva, Martínez-A, Carlos, Campuzano, Sonsoles, Torres, Miguel
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2002
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126101/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12093734/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf354
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