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Binding of tobramycin leads to conformational changes in yeast tRNA(Asp) and inhibition of aminoacylation
Aminoglycosides inhibit translation in bacteria by binding to the A site in the ribosome. Here, it is shown that, in yeast, aminoglycosides can also interfere with other processes of translation in vitro. Steady-state aminoacylation kinetics of unmodified yeast tRNA(Asp) transcript indicate that the...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2002
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125865/ https://ncbi.nlm.nih.gov/pubmed/11847123 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.4.760 |
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