Binding of tobramycin leads to conformational changes in yeast tRNA(Asp) and inhibition of aminoacylation
Aminoglycosides inhibit translation in bacteria by binding to the A site in the ribosome. Here, it is shown that, in yeast, aminoglycosides can also interfere with other processes of translation in vitro. Steady-state aminoacylation kinetics of unmodified yeast tRNA(Asp) transcript indicate that the...
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| Vydáno v: | EMBO J |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2002
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125865/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11847123/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.4.760 |
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