Binding of tobramycin leads to conformational changes in yeast tRNA(Asp) and inhibition of aminoacylation

Aminoglycosides inhibit translation in bacteria by binding to the A site in the ribosome. Here, it is shown that, in yeast, aminoglycosides can also interfere with other processes of translation in vitro. Steady-state aminoacylation kinetics of unmodified yeast tRNA(Asp) transcript indicate that the...

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Detalles Bibliográficos

Publicado en:	EMBO J
Principais autores:	Walter, Frank, Pütz, Joern, Giegé, Richard, Westhof, Eric
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Publishing Group 2002
Assuntos:	Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125865/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11847123/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.4.760
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